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Distinctive examples are provided to highlight the state-of-the-art technologies that significantly advance basic and clinical cancer research.

Keywords: Gold nanoparticle, circulating cancer marker detection, circulating tumor cell, extracellular vesicle, circulating nucleic acid, protein tumor marker. Liu X, Dai Q, Austin L, Coutts J, Knowles G, Zou J, Chen H, Huo Q.

Identification of such biomarkers in clinical samples would improve the early detection of organ injury, help identify appropriate preventive or curative strategies, preventing organ injury into organ failure, and improving the quality of life.

It has been demonstrated that detection using a panel of biomarkers, provides greater sensitivity and specificity for assessing the presence and extent of a disease or injury process than with the use of a single biomarker.

Probit linear regression models were used to combine the analytes into score functions to address the following clinical questions: does the biomarker test augment PSA for population screening?

Can aggressive disease be differentiated from lower risk disease, and can the panel discriminate between prostate cancer and benign prostate hyperplasia?

Tissue biopsy is commonly used in the clinic to diagnose a variety of cancers. A simple and sensitive impedimetric aptasensor for the detection of tumor markers based on gold nanoparticles signal amplification. A one-step homogeneous immunoassay for cancer biomarker detection using gold nanoparticle probes coupled with dynamic light scattering.

These indicators can be a number of different substances including nucleic acids, proteins and small molecules (Figure 1).

Received date: January 27, 2017; Accepted date: February 06, 2017; Published date: February 08, 2017 Citation: Ravipaty S, Wu W, Dalvi A, Tanna N, Andreazi J, et al.

(2017) WClinical Validation of a Serum Protein Panel (FLNA, FLNB and KRT19) for Diagnosis of Prostate Cancer. doi:10.4172/2155-9929.1000323 Copyright: © 2017 Ravipaty S, et al.

Theranostics International Journal of Biological Sciences International Journal of Medical Sciences Journal of Cancer Journal of Genomics Journal of Bone and Joint Infection Journal of Biomedicine Oncomedicine This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). How to cite this article: Huang X, O'Connor R, Kwizera EA. Available from of cancer-related circulating biomarkers in body fluids has become a cutting-edge technology that has the potential to noninvasively screen cancer, diagnose cancer at early stage, monitor tumor progression, and evaluate therapy responses. His research is to improve the detection and analysis of circulating tumor cells through the use of surface enhanced Raman scattering nanoparticles and microfluidics platform.

Gold Nanoparticle Based Platforms for Circulating Cancer Marker Detection. Traditional molecular and cellular detection methods are either insensitive for early cancer intervention or technically costly and complicated making them impractical for typical clinical settings. degree in chemistry from Georgia Institute of Technology in 2006 and postdoctoral training at Georgia Institute of Technology and Emory University from 2006 to 2010. Elyahb Allie Kwizera received his bachelor's degree in chemistry and mathematics from the University of Central Arkansas in 2014.

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